Chlorpyrifos (CPF) is one of the widely used organophosphate which is one of the few discovered chemicals to be the developmental neurotoxicant as it targets the critical period of developmental maturation of brain and targets the behavioral development. Many noncholinergic and cholinergic mechanisms are involved commencing the disrupted cell replication, axogenesis and the differentiation leading to neurobehavioral impairments with a number of developmental disabilities which are diagnosed in children at an alarming increasing rate. These persistent decrements in developmental abilities may well presage later development of neurodegenerative disease thus may lead to neurodegenerative diseases. All these above-mentioned mechanisms ultimately lead to enhanced oxidative stress. Therefore during the pregnancy, the natural antioxidants which are reported to have no side effects can be investigated as the treatment against CPF intoxication protecting the developing fetus brain. Apart from the above discussed antioxidants, certain Ayurvedic products having no side effects during the pregnancy and on the neural growth and development should be investigated and explored against CPF intoxications. There are certain such natural products discussed which can be the treatment against neurodegenerative effects in developing brain. Therefore, these natural products must be investigated for their therapeutic potential against CPF intoxication in developing brain leading to adverse neurobehavioral impairments and neurogenerative ailments.