Cytomegalovirus Retinitis in Immunosuppressed Patients: Case Studies - Abstract
Introduction: CMVR is the most common opportunistic ocular infection in severely immunocompromised individuals. Herein, we report three immune deficient patients with CMVR.
First case: A 15-year old girl with the diagnosis of HIV infection and diffuse large B-cell lymphomaadmittedto hospital with the complaint of blurred vision on her left eye. She was then diagnosed as CMVR. She was started on chemotherapy together with antiretroviral treatment. CMVR fully resolved after 6 months of parenteral and intravitreal ganciclovir therapy.
Second case: A 17-year old boy with the diagnosis of PID (IL-21 receptor deficiency) admitted with the complaint of diminished visual acuity. Absolute CD4 count was 50 cells/mm3 and fundoscopic examination revealed CMVR. Although several antiviral agents were administered, progression of the disease could not be prevented.
Third case: A4-month old girl with the diagnosis of SCID was diagnosed as bilateral CMVR after fundoscopic examination which had been performed during CMV viremia. She was given systemic ganciclovir and foscarnet treatment. Unfortunately she passed away because of disseminated CMV infection.
Conclusion: Routine ophthalmologic examinations for CMVR should be performed in immunocompromised patients.