Depression in older adults is a major public health problem that has received an inadequate response from medical professionals. Symptoms of depression can differ from those of younger adults and be related to cognitive changes, physical health problems, and limited social interactions. Depression in older adults can be successfully prevented and treated. Treatment options include antidepressant medication, psychotherapy, and Neuromodulation therapies in cases of severe depression. Programs developed for the treatment of older adults with depression show positive results. Recommendations are offered to improve screening, assessment, and referral for appropriate treatment. Depression is a common mental disorder in the United States affecting children, adolescents, adults, and older adults. This article explores the relationship between aging and depression, focuses on symptoms of depression in older adults, examines types of treatment, and offers recommendations to screen, assess, and treat older adults. With the number of older adults expected to increase significantly in the United States in the coming years, it is of critical importance to address prevention and treatment of depression in older adults.