Anxiety among medication overuse headache (MOH) patients was assessed. The primary objective of this study was to examine the relationship between anxiety and health related quality of life among medication overuse headache (MOH) patients in group of 600 new diagnosed MOH patients. The study showed a positive correlation between the anxiety and duration of MOH. Anxiety is showed as a risk factor for development of MOH. Anxiety was singled out as a risk factor for the overall aspect of health in MOH sufferers (p = 0.05). The study found that the duration of the earlier chronic headache positively correlated with the impact of MOH (r = 0.327, p = 0.003). The impact of MOH as well as anxiety were on all domain of health and assessed as significant, correlating with the duration of the MOH (p ? 0.05). Assessment of anxiety in MOH patients could be important for improving their quality of life.