BDNF: An Emerging Prognostic Marker in Bipolar Disorder: Mini Review - Abstract
Brain Derived Neurotropin Factor (BDNF) is a well-known potential biomarker used in studying the neurophysiological mechanisms either as a diagnostic or prognostic marker. Current research is trying to explore its putative role in chronic psychiatric illness termed Bipolar Disorder (BD). BDNF has been found to be expressed in Bipolar Disorder at various time variants based on the disease severity.
Various studies have been conducted using differential approach to evaluate th pathophysiology behind the variation in the disease severity and its correlation with BDNF expression in the clinical outcome.
Due to an existence of substantial variations in the clinical outcome and heterogeneous pathophysiology of the disease, no research has come up with prompt conclusion in relevance to diagnostic or prognostication. The aim of this mini review is to highlight the core relationship of BDNF in BD using peripheral molecular marker and its role in the disease specificity in relation to the disease severity, its relevance in the future direction implementation.