Prevalence of Thyroid Dysfunction and Its Relationship with the severity of Major Depressive Disorder - Abstract
Aim: To examine the prevalence of thyroid dysfunction in Major Depressive Disorder and its correlation with the severity of MDD.
Method: 140 major depressive disorder patients received blood sampling to identify any thyroid dysfunction. The severity of illness was determined by using the Hamilton rating scale for depression (HAM-D), frequency of admission and suicidal attempts.
Results: There were 140 subjects recruited. (95 female, 45 male) 31 of 140(22.1 percents) had thyroid dysfunction. Comparing patient who had thyroid dysfunction with patient who had normal blood level, there is no significant different in duration of illness, Hamilton rating scale for depression (HAM-D), frequency of admission and suicidal frequency (p = 0.22). But by using Spearman correlation there is negative correlation between free 3,5,3’-triiodothyronine (T3) and score of HAM-D(p = 0.024).
Conclusion: MDD patients had high prevalence of thyroid dysfunction that did not correlate with their severity.