Advances in signaling pathways in the non-bone phase mechanism of f luorosis - Abstract
Fluorine is an essential trace element, and excessive or insufficient intake can lead to damage. Currently, fluorosis has been studied more in the bone phase, but less in the non-bone phase of fluorosis. The pathogenesis of fluorosis is complex and unclear. Signaling pathways have been a popular area of exploration in disease pathogenesis, Signaling pathways play an important and irreplaceable role in the pathogenesis of fluorosis in recent years as well. In this paper, we summarize the relevant signaling pathways to provide a basis for the pathogenesis of fluorosis-induced non-osteopathic systems and hope to obtain effective preventive and therapeutic measures.