Introduction: In previous work, moderate leg exercise stress 4 weeks apart did not produce contralateral repeated bout injury protection (exercise induced acute injury in one limb protecting against later induced injury in the other limb). Aim: A new study used the same stress protocol, but tested for whether protection could occur with a shorter lag time (10 days). Results: In 31 young adult fitness trained males, moderate injury was produced by a leg extension exercise protocol in one leg and then 10 days later in the other leg. Partial protection was seen based on perceived soreness at 1 and 2 days later (p = 0.02/0.01, paired t test for bout 1 vs bout 2). In addition, protection was seen for leg extension performance at the end of the leg stress (p = 0.01, paired t test for bout 1 vs 2). Creatine kinase assessments were too inconsistent to be useful. Conclusion: Protection transfer between limbs may depend on the stress intensity, the type of protocol and measures used, and time between stress exposures.