Infectious diseases are responsible for debilitating livestock production causing substantial economic losses to agricultural sector throughout the globe. Conventional disease control strategies being fruitful, have managed the situation to a larger extent however, limitations to traditional control methods paved way for advancing techniques as alternative strategies. As advancement in medical field, immunization remains a developing sphere responsible for alleviation of negative effects of fatal diseases. The formulations containing pathogenic substances are capable of providing immunity for lifetime that has revolutionized the concept of immunization. Vaccination has emerged as a standard method for controlling disease and further turned out to be an essential approach to deter disease development. It has been reported to be responsible for high production of livestock which would not have been achieved otherwise. Nonetheless, these approaches still have significant disadvantages, providing a window to include advanced techniques in this area thereby directing the search for vaccine production grounded on a protective recombinant protein. The development of recombinant subunit vaccine is one of the approaches marked as an innovative control strategy alternative to conventional vaccines receiving support from growing scientific studies. To further, their effectiveness is yet to be explored so the need of an hour is to investigate additional strategies for enhancing recombinant vaccine efficacy in commercial settings.