Rabies is an under reported disease that is present on every continent except Antarctica. It is estimated that 59 000 human deaths occur annually across the world. Most human deaths occur in Africa and Asia . World Health Organization (WHO) and the World Organisation for Animal Health (OIE), in collaboration with the Food and Agriculture Organization of the United Nations (FAO) and supported by the Global Alliance for Rabies Control (GARC), developed a global framework for the elimination of dog-mediated human rabies by 2030. Rabies is preventable through timely administration of post-exposure prophylaxis (PEP).PEP has three components: (a) local wound treatment (b) vaccine administration and(c) administration of rabies immune globulin (RIG) in all category III exposuresThe primary objective of PEP is to neutralize and destroy virus that was inoculated into a victim’s body at the time of exposure. Rabies vaccines, especially Cell Culture Vaccines, have proved to be highly effective in preventing human rabies.Vaccines induce active immunity and have an important role in protecting the individuals, as the host response to the infectious agent in a vaccinated person will be fairly rapid and sufficient to prevent the occurrence of the disease.