Decompression Sickness (DCS) is a condition consisting of complications/symptoms after diving. Main pathophysiological event involves formation of inert gas bubbles in tissues and microcirculation (usually Nitrogen or Helium), that target multiple organs and tissues. Identification of lesions, among other investigations, is associated with biochemical and enzymic changes as a result of cellular damage. We report a case of DCS causing neurological damage associated with significant changes in blood tests. Treatment with Hyperbaric Oxygen Therapy (HBO2) led to resolution. Case report: A 37-year-old male diver was transferred to the Athens Naval Hospital with symptoms after diving. He developed neurological deficit manifesting as asymmetrical nystagmus, reduced motor power in the right lower extremity (4/5) and a rash of upper extremities and torso. Treatment strategy involved initial management of symptoms with normobaric oxygen 100% and fluid resuscitation, followed by recompression therapy and HBO2 combined with medication to resolve neurological injury. Ten days later following remarkable clinical improvement he was discharged.