Objectives: To describe the clinical profile and outcomes of pregnant women with COVID-19–related ARDS who underwent prone positioning in a tertiary referral center. Design: Retrospective observational study. Setting: Tertiary university hospital in southern Brazil. Patients: Pregnant women ?18 years admitted to the ICU with confirmed COVID-19 and managed with prone positioning (2020–2021). Measurements and Main Results: Seven patients were included. Mean age was 27.4 ± 3.8 years, mean gestational age 29.1 ± 3.8 weeks, mean BMI 33.1 ± 4.6 kg/m², and mean SAPS III 52.7 ± 10.1. Three (42.9%) had diabetes, two (28.6%) hypertension, and one (14.3%) was a smoker. Six (87.5%) required vasopressors, and one (14.3%) received inhaled nitric oxide. Proning sessions ranged from 1 to 7. Four patients (57.1%) developed stage 1–2 pressure injuries, all of which resolved. No major adverse events (accidental extubation, ocular injury, or brachial plexus injury) were reported. Three patients (42.9%) died. All neonates were delivered alive. Conclusions: Prone positioning was feasible and did not result in major maternal complications in pregnant women with COVID-19–related ARDS, including in the second and third trimesters. Larger studies are needed to confirm maternal and fetal safety.