Repair of bone defects, orthodontic tooth movement, and alveolar bone remodeling involve bone, and the osteogenic differentiation potential of human periodontal stem cells closely affects alveolar bone repair and bone regeneration. The ncRNA (non-coding RNA) play an important role in the regulation of osteogenic differentiation genes of human periodontal stem cells, which is expected to be a new strategy for solving clinical bone-related problems in dentistry. In this paper, we review the progress related to the role of ncRNA on osteogenic differentiation of human periodontal stem cells.