Curcumin has long been recognized for its potential pharmacological effects. However, its bioaccessibility and bioavailability remain low. To address this limitation, we evaluated the efficiency of delivery via curcumin-encapsulated ?-cyclodextrin metal-organic frameworks (Cur-?-CD-MOFs), in comparison to coarse emulsions formulated with sodium caseinate and Tween 80, using simulated in vitro gastrointestinal digestion. Bioaccessibility of curcumin was highest when encapsulated in ?-CD-MOFs, if delivered as a capsule to avoid exposure to gastric conditions, achieving a sixfold increase compared to native (non encapsulated) curcumin and significantly higher than the emulsion systems if exposed to gastric conditions (due to the structural instability of ?-CD-MOFs under acidic gastric conditions). It was also demonstrated that, prolonged solubilization of curcumin via capsule-delivered ?-CD-MOFs throughout in vitro gastrointestinal digestion enhanced its transport and absorption across the mouse intestinal epithelial tissue. This highlights the potential of ?-CD-MOFs as an effective delivery system for improving bioaccessibility and absorption of bioactive compounds. Highlights ?Cur-?-CD-MOFs delivered as a capsule enhance curcumin bioaccessibility ?Cur-?-CD-MOFs degrade in emulsions under gastric (acid) conditions Ex vivo Using chamber validates improved intestinal absorption via CD-MOFs