Clinical decisions in HIV infection are based on the CD4 lymphocyte count. Some studies have reported a downward tendency in absolute CD4 count with liver cirrhosis which could make it more useful to use percentage CD4 values. A study was made to determine whether the Fibroscan® (F) findings are related to the existence of discordance between the absolute and percentage CD4 counts, and to evaluate the possible existence of an F cutoff point indicating the use of %CD4 instead of the absolute count. In a first sample of 60 individuals, validated with data on 50 cases from another hospital, an analysis was made of the relationship between the Fibroscan® results and discordance of the absolute versus the percentage CD4 counts. Above 7 Kp (with high sensitivity) and above 32 Kp (with high specificity), the clinical decisions should be based on %CD4, not on the absolute counts.