Study was undertaken to assess the response of Brassica campestris L. exposed to different metals {Cu, Cr(VI), As(III), As(V)} on accumulation, antioxidants, nutrient status, toxicity and oil yield. Results showed translocation of metals to the upper part and its sequestration in the leaves without significantly affecting seed weight and oil yield. In seeds, accumulation of as was below detection limit, however, the accumulation of 3.15 mg/kg of Cr was recorded. Seeds collected from Cu treated plants have shown no difference in essential metal content as compared to control. Amongst the four metal treatments, Cr was the most toxic as evident from the decrease in growth parameters and chlorophyll content along with increase in malondialdehyde content. The activities of antioxidant enzymes varied for different metals. In view of these findings, Brassica campestris L. can be recommended for cultivation on as and Cu contaminated soil for oil production only.