Phytochemical, proximate and mineral compositions of leaves and stems of Stachytarpheta cayennensis (L.C. Rich.) Vahl and S. indica (Linn.) Vahl were evaluated using standard methods and compared. Protein, fat and minerals as well as certain bioactive agents: alkaloid, flavonoid, saponin, sterol and tannin were detected in various concentrations. Higher concentrations of fat and protein as well as all the micronutrients were present in the stems of S. indica. Concentrations of alkaloid were higher in the leaves and stems of S. cayennensis where as higher level of protein was detected in the leaves. Greater level of hydrogen cyanide was found in the leaves of the two plants. Data were considered statistically significant at P?0.05. However, high concentration of hydrogen cyanide, an acute toxin, detected in both the leaves and stems of the plants render them inedible without proper processing. Thus, the utilization of these plants in ethno medicine as food and drug could be fatal; therefore, it is highly discouraged. Nonetheless, the bioactive compounds and nutrients could be extracted for development of drugs and food supplements.