Obesity is a strong risk factor for various diseases, such as hypertension, arteriosclerosis and diabetes. Therefore, an effective way to prevent obesity is to inhibit fat absorption from intestines. Pancreatic lipase is a key enzyme for lipid absorption. One of the approaches to reduce obesity is treatment with natural products. Many plants have been reported to inhibit lipase activity which is attributable to the presence of secondary metabolites such polyphenols, benzopyrones whose members include flavonoids, saponins, coumarins etc. are active inhibitors of pancreatic lipase. In our study using porcine pancreatic lipase, a series of plants were screened for their pancreatic lipase inhibitory activities. According to the results; green apple, green tea and avocado extracts had the highest antilipase activities. These plants based diets may be involved in weight control programs.