Heavy metals (HMs) pollution of soils is an environmental problem which had negative impact on agriculture and human health. In this review, we focused on the use of legumes co-inoculated by HMs tolerant plant growth promoting bacteria (PGPB) in phytoremediation of HMs contaminated soils. Legume-HMs resistant PGPB symbiosis is an eco-friendly approach for phytoremediation of HMs contaminated soils, since it provides additional N-compounds to the soil by symbiotic nitrogen fixation(SNF) through nodule of rhizobia, in addition, PGPB were very effective and possessed plant growth promoting (PGP) traits such as solubilization of phosphate, production of phytohormones and siderophores which induced plant growth, as well as changing bioavailability of HMs in soil through various mechanisms such as bioaccumulation, chelation, acidification, protonation, precipitation and complexation. HMs stress induced a wide range of physiological and biochemical tolerance mechanisms such as the expression of metal binding proteins involved in chelation and HMs transporting proteins employed in active transport of ligand-metal complex into vacuole such as Glutathion GSH, Phytochelatins PCs, Metallothionin MTs, organic acid and amino acid HMs contamination caused generation of reactive oxygen species (ROS) in plant organs that causes oxidative stress. Plants respond by activation of enzymatic and non enzymatic antioxidant defense system suggesting that certain of them could be markers of HMs tolerance. HMs tolerant PGPB improve the performance of phytoremediation in legumes either by reducing HMs accumulation in the aerial part of plants and it’s enhancing to roots and nodules in phytostabilization process, or by increasing the uptake of HMs in plant organ and their translocation to the aerial parts in phytoextraction approach. So, selection of suitable resistant PGPB and legumes species for an efficient symbiosis in phytoremediation can be developed. However, each contaminated ecosystem should be considered for their specificity, which presents the main difficulty for large spectre PGPB biofertilizer development.