A field experiment was conducted in farmer’s field of two locations under High Ganges River Floodplain (AEZ-11) of Bangladesh during 2013-2014 cropping season for evaluating the comparative suitability regarding yield and economic performances of six newly released sugarcane varieties viz, Isd 34, Isd 36, Isd 37, Isd 38, Isd 39 and Isd 40 with the old popular variety Isd 16. The experiment was laid out in a Randomized Complete Block (RCB) design with three replications. At Chuadanga the highest cane yield of 112.54 t ha-1 was obtained in Isd 37 which is statistically similar with Isd 39 and Isd 40 and the lowest yield was obtained in Isd 34. But at Jessore the maximum yield of 110.19 t ha-1 was recorded from Isd 39 followed by Isd 37 (99.22 t ha-1) and the minimum from Isd 36. Similarly, the newly released varieties Isd 37, Isd 39 and Isd 40 gave higher economic return compared to old variety Isd 16 in High Ganges River Floodplain of Bangladesh. Therefore, these three sugarcane varieties can be cultivated in this area with recommended management practices for acquiring higher yield and economic benefit.