Conducted on a cohort of 150 patients followed at the Respiratory Diseases Department of the 20 August 1953 Hospital in Casablanca between 2019 and 2023, this retrospective and analytical study outlines the profile of severe asthma in a Moroccan referral center. The study population has a mean age of 36 years with a female predominance (58%) and high exposure to environmental humidity (46%), while the clinical profile is dominated by allergic rhinitis (56%) and gastroesophageal reflux disease (26%). Functionally, the study reveals severe bronchial obstruction with a mean FEV1 of 54% and, alarmingly, an irreversible obstructive ventilatory defect in 68% of cases, confirming the significance of airway remodeling and the difficulty of control (64% uncontrolled patients), which justifies a multidisciplinary therapeutic approach including biological therapies.