Fibromyalgia is a complex and common musculoskeletal syndrome characterized by chronic and widespread pain and other associated somatic and psychological symptoms that significantly compromise quality of life. In last years, various pathogenetic hypotheses have been described, including the role of inflammation and oxidative stress in the development of this syndrome. To date, there are many, but not resolutely pharmacological approaches, like antidepressants, which are not fully effective against the wide spectrum of fibromyalgic symptoms and, unfortunately, they are associated to many side effects. Among emerging strategies evaluated to counteract fibromyalgia, melatonin has been shown to be suitable and useful in its management because of its numerous and multiple .In this review, we present a brief overview of the emerging potentiality of melatonin in the management of fibromyalgia, reporting the few clinical trials in which melatonin was tested and presenting a possible melatonin mechanism of action against fibromyalgia alterations in vivo.