Phoenix sylvestris is a very graceful palm which is also known as Wild date palm, Silver date palm, date sugar palm and belongs to the family Arecaceae. The various parts of plant reported possessing diuretic, analgesic effect, anti-inflammatory, antibacterial and neuropharmacological activities. Phoenix sylvestrisis traditionally claimed to have antidiabetic, antidiarrheal, anti-dysentery activity and used in the treatment of a toothache, menstrual complaint. Our aim of the study to performed molecular docking studies to identify potential binding affinities of the phytocompounds from Phoenix sylvestris, namely 4-methylcatechol towards ?-amylase for searching of the lead molecule against diabetes. A wide range of docking score found during molecular docking by Schrodinger. 2, 3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 4-methylcatechol showed the docking score respectively -5.044 kJ/mol and -5.303 kJ/mol against ?-amylase. Between all the compounds 4-methylcatechol showed the best docking score towards ?-amylase. So, 4-methylcatechol is the best compound for ?-amylase enzyme inhibition, as it possessed the best value in Molecular Docking. Further, in vivo investigation need to identify ?-amylase enzyme inhibitory activity of isolated compounds from Phoenix sylvestris.