Network-Based Protein-Protein Interaction Analysis - Abstract
High-throughput experimental technologies in protein interaction continue to alter the study of current system biology, and a large-scale data can be available. Protein-protein interactions on these experimental platforms, however, present numerous production and bioinformatics challenges. Some issues like the functional modules identification, protein complexes prediction, protein function prediction and disease-related gene prioritization have become increasingly problematic in the analysis of protein-protein interaction networks. The development of powerful, efficient prediction methods for the structure and function analysis of protein interaction network is critical for the research community to accelerate research and publications. Currently, Network-based approaches are drawing the most attention in analyzing protein interactions. This review aims to describe the-state-of-art of network-based strategies and applications to infer protein interactions.