Protein Structure Fingerprint Technology - Abstract
Knowledge of protein structures is significant for biology research and drug discovery. The protein 3D structures may be obtained by experimental measurements or computational approaches. Experimentally, the protein structures can be measured by X-ray crystallography, Nuclear Magnetic Resonance (NMR) or Transmission Electron Cryomicroscopy (Cryo TEM) etc., and so far over 140,000 of 3D structure data are available in PDB (Protein Data Bank) (https://www.rcsb.org/). Experimental measurements may accurately determine atomic coordinates of protein structures which are only some of snapshots for stable states under specific conditions.