Background: Charcot Arthropathy (CA) is a severe, progressive joint disorder, most commonly associated with diabetic neuropathy, that poses a significant global clinical challenge due to its destructive nature and potential for limb loss. Despite decades of research, a comprehensive, data-driven overview of the global research landscape, its intellectual structure, and evolving trends has been lacking. Objective: This study aimed to conduct the first systematic bibliometric analysis to map the scientific literature on CA from 1995 to 2025, delineating the field’s development, key contributors, research hotspots, and emerging frontiers. Methods: We retrieved 349 relevant articles and reviews from the Web of Science Core Collection. Using bibliometric tools including Cite Space and the R package bibliometrix, we performed quantitative analyses of annual publication trends, country/institution contributions, author and collaboration networks, core journals, co-cited references, and keyword co-occurrence and bursts. Results: The analysis revealed a consistent rise in annual publications, signaling growing research interest. The United States was the dominant contributor, producing the highest volume of publications (n=180) and citations (n=3,949), and acting as the central hub in international collaboration networks. Key influential authors (e.g., Dane K. Wukich) and institutions (e.g., University of Texas System) were identified, forming tightly-knit academic communities. Journal analysis confirmed a strong clinical-surgical focus. Research hotspots persistently centered on the foot/ankle region, pathogenesis, and surgical management. Analysis of keyword bursts and reference clusters indicated a shift towards emerging frontiers, including biomechanics, advanced reconstruction techniques, and the application of 3D imaging. Conclusion: This study provides the first macroscopic mapping of CA research over three decades, objectively identifying the United States as the field leader and highlighting a clear evolution towards technology-enhanced diagnosis and management. The findings offer an authoritative reference for clinicians and researchers to understand the field’s core structure and future directions, underscoring the need for broader global collaboration and the integration of novel technologies into clinical practice.