Aim of this work is to verify the various use of AI in chemical settings and the benefit and risk in using this innovative technology. AI tools like make possible to have powerful instrument in study or in researcher as well as in the various chemical discipline. After a review of some interesting literature related some interesting use of AI and the risks involved the results of an experimental project involved the use of a famous free AI – CHATBOT (question and answer). Crucial in this world is that the results provided must to be the right one , without relevant error or the so called “hallucinations”. The final human control of the AI results can be a useful method to use in a safety way this technology today.