Diagnosis and management of cavernous sinus thrombosis can be challenging, but several clinical clues can aid in a more time-efficient and cost-effective approach. This condition is rare which can delay diagnosis and be fatal due to the several important neurovascular structures that run through the cavernous sinus. This report discusses a case of cavernous sinus thrombosis in a male with substance use disorder whose signs, symptoms, and diagnostic findings were classic for the condition. Prompt recognition of these can lead to a more rapid diagnosis and early initiation of adequate treatment. There are limited evidence-based guidelines regarding diagnosis and treatment. This report will also review some of the more recent literature on the topic to aid healthcare providers in giving proper care for their patients and thereby increasing knowledge and awareness of the subject.