Reactive infectious mucocutaneous eruption (RIME) is a rare syndrome characterized by mucosal and cutaneous involvement secondary to an underlying infection. This report describes a case of a 24-year-old male who presented with fever, cough, congestion, sore throat, conjunctivitis, and fatigue. Initial evaluation revealed elevated inflammatory markers and Mycoplasma infection. Following hospitalization, the patient developed severe irritation and lesions involving the oral, ocular, and genital mucosa, consistent with RIME. Management included azithromycin and supportive care. The patient initially presented to a community hospital, but due to limited availability of dermatology, ophthalmology, and urology consultation services, he was transferred to a tertiary care facility for further specialized care. This case highlights the importance of recognizing RIME in the context of infectious triggers and provides insights into its clinical management and outcomes.