Introduction: Non-compaction of the left ventricle (NCVG) is an under-diagnosed cardiac pathology with major complications. We describe a case of LVNC complicated by intraventricular thrombi followed by hemispheric ischaemic stroke. Clinical presentation: The patient was 24 years old, primigravida and primiparous, with no previous pathological history, and was admitted for dyspnoea. Physical examination revealed general condition stage III (WHO performance status), paleness of conjunctivae and mucous membranes, blood pressure 130/88 mmHg, congestive heart failure syndrome, mitral insufficiency murmur intensity 3/6. Echocardiography showed hypertrabeculation inside the left ventricle, which was very vascular on colour Doppler, with three trombi in the left ventricle. The patient was treated with furosemide 80 mg daily, enalapril, Aldactone for heart failure and curative enoxaparin. The 48-hour course was marked by the sudden onset of total right hemiplegia with Brocca aphasia. A subsequent CT scan revealed a left hemispheric ischaemic stroke. The patient died 24 hours after her neurological event due to respiratory distress. Conclusion: This case highlights the diagnostic and therapeutic issues associated with non-compaction cardiomyopathy. It is a condition that is still poorly understood, with a high risk of complications.