Rhabdomyolysis is a complex condition caused by damage or injury at the muscle level, which can generate complications at the level of multiple organ systems. The clinical presentation of this entity is variable, but creatine kinase levels are the most sensitive test for diagnosis. Among the most important causes of rhabdomyolysis is the use of drugs, among which statins stand out and pregabalin has recently been described as one of the pharmacological causes. The evidence of this adverse event is scarce at international level, with 4 case reports of rhabdomyolysis associated with pregabalin, 2 of them presented in patients using statins. It should be considered that the evidence of this adverse event is null at the national level. We present the clinical case of a 73-year-old patient, a chronic statin user who presented myalgia associated with the recent incorporation of pregabalin to his pharmacological therapy.