Two Patients with Rapidly Developing of Castration-Resistant Prostate Cancer: A Case Report and Update of Literature - Abstract
Abstract Prostate Cancer (PCa) is one of the most common malignancies in men worldwide. Androgen Deprivation Therapy (ADT) is a cornerstone in the management of patients with metastatic hormone-sensitive prostate cancer. Recently, researchers found the presence of a subset of PCa cells with intrinsic properties of castration-resistance in hormone-naïve PCa. These pre-existing castration-resistant cells can rapidly expand during ADT and lead to the development of Castration-Resistant Prostate Cancer (CRPC). We describe two patients with quickly development of CRPC, for whom further treatment was not beneficial. The histopathological and clinical presentation of PCa thus shows strong heterogeneity. To achieve precision medicine, further research should focus on the development and deployment of biomarker-selected targeted therapies. Patients with quickly developing of CRPC at diagnosis can then possibly be selected for alternative treatment strategies