The Functions of CHIP in Age Related Disease - Abstract
CHIP is a key component of the protein homeostasis or ‘Proteostasis’ network that maintains protein structure and function as a way to ensure the integrity of the proteome in individual cells and the health of the whole organism. Proteostasis influences the biogenesis, folding, trafficking and degradation of proteins. Originally identified as a Hsc70 associated protein and a co-chaperone CHIP has E3-ubiquitin ligase activity and also displays an intrinsic chaperoning ability. It has become clear that CHIP is a multi-functional protein with roles in cellular processes that go beyond its co-chaperone activity. Not surprisingly, by unravelling the functions of CHIP, we are beginning to appreciate that loss of CHIP’s integrity can lead to the development of several serious pathological conditions. Here we will describe the key features of CHIPs structure and functions with an emphasis on the non-canonical activities of CHIP before concentrating on the role it plays in protecting against the age associated pathologies of neurodegeneration and cancer.