Genetic Perspective of Corneal Endothelial Dystrophies - Abstract
The corneal endothelium serves primarily in maintaining stromal deturgescence which is essential for transparency of cornea. Any disturbance in its function leads to stromal edema which in turn reduces vision. The genetically heterogeneous nature of four different kinds of corneal endothelial dystrophies represents the involvement of diverse set of genes. Until now, only few genes were identified for a subclass of corneal endothelial dystrophy. Therefore, in this review, elucidated genes and their function involved in different corneal endothelial dystrophies were described to understand the pathogenesis of the disorder.