Head-neck carcinoma (HNC) affects more than 500000 people in the world, but Head-neck metastases (HNM) are a rare feature in the clinical practice, especially if they are secondary to other primitive such as different solid tumors. Diagnosis can be difficult and origin sites can be different, so patient management has many critical points. We report our experience in order to demonstrate we should not underestimate the possibility to study different site of origins when in presence of HNM. The most frequent HNM localization in our experience was laterocervical region with asymptomatic swelling as most common clinical manifestation. Lung was most frequent origin site, followed by mammary gland. Prognosis of HNM patients is often poor, so diagnosis should be tempestive and treatment assigned to a multidisciplinary team.