Background and Objectives: Despite comprehensive preoperative cardiovascular assessment, cardiovascular events remain a leading cause of postoperative mortality, due to the complexity of liver transplantation surgery. Therefore hemodynamic monitoring during liver transplantation is crucial. With PICCO (Pulse Index Continuous Cardiac Output) technology, hemodynamic parameters such as cardiac power index (CPI) can be follwed during surgery. The aim of this study is to investigate the relationship between CPI and postoperative secondary myocardial infarction. Method: A total of 53 patients were included in the study. Patients divided into two groups according to the presence or absence of myocardial injury following liver transplantation. Results: Postoperative myocardial injury (PMI) was observed in 28.3%(n=15) of these patients. ?CPI was significantly lower in patients with PMI (-0.27 ± 0.11 W/m²), than those without PMI (0.08 ± 0.18 W/m²) (p<0.05). The multivariate analysis showed that the only independent predictor of PMI was ?CPI (HR: 2.245, 95% CI: 1.145 – 4.387, p: 0.032). ROC analysis that revealed ?CPI values lower than -0.15 W/m² were significantly associated with PMI. Peak troponin level, hospital stay and myocardial infaction prevelance were significantly higher in ?CPI ? -0.15 W/m² group (all p < 0.05). Conclusion: Our data shows that ?CPI which constitutes the decrease in CPI during transition from the anhepatic phase to the neohepatic phase, can be used as a marker of poor cardiac prognosis in patients who underwent liver transplantation