Accelerating Biological Neovascularization in Chronic Limb Threatening Ischemia - Abstract
Chronic Limb-Threatening Ischemia (CLTI) was managed in patients who failed previous invasive revascularization. A novel non-invasive, home-based approach designed to improve blood flow by addressing eight obstacles to innate neovascularization was used. Hemodynamic evidence of improved blood flow was evident in 14 of 15 patients and was substantiated by angiographic evidence of collateral artery growth and segmental re-canalization of chronic thrombus. These substantiate our previously reported molecular evidence of endothelial activation, increase in pro-angiogenic cellular and protein mediators, low-grade fibrinolysis, and improved cellular immunity. Limb salvage for at least one year was achieved in 12 of 15 despite being “no option” CLTI patients. Recommendations for further study are made to assess this modality in CLTI as well as in other ischemic conditions