Introduction: Duodenal diverticula are weakened mucosal outpouchings that are most frequently located in the second portion of the duodenum, neighboring the ampulla of Vater. Most diverticula are acquired and asymptomatic. Presentation of case: A 46-year-old female presented with complaints of recurrent intermittent epigastric pain associated with nausea and vomiting for duration of one year, and was incidentally found to have a hemoglobin level of 5.0 g/dL. She was worked up by a gastroenterologist and an upper endoscopy revealed a dilated duodenum. A CT scan confirmed the diagnosis of a duodenal diverticulum and the patient successfully underwent duodenal resection. Discussion: Duodenal diverticula are common and are usually discovered incidentally. Here, we present a case report and a review of the literature in an effort to increase the awareness of signs, symptoms, demographics, and possible complications of small bowel diverticula. Signs and symptoms of a duodenal diverticulum are highly variable, and depend on the associated complications. Conclusion: Duodenal diverticula are common, but are often missed by clinicians. Signs, symptoms and complications vary. Familiarity with the various modes of presentation will help clinicians diagnose and manage diverticula, as well as prevent further complications.