Effects of Antibiotics on Microbiome-Associated Diseases - Abstract
The gut microbiome is crucial for drug action, bioavailability, and toxicity, affecting host physiology and health, including brain health. Dysbiosis, or disruptions in the gut microbiome, is linked to various diseases, such as inflammatory bowel diseases, obesity, and metabolic syndrome. Antibiotics, used to treat bacterial infections, can disrupt the gut microbiome, leading to Antibiotic-resistant organisms and overgrowth of opportunistic pathogens. This disruption can result in toxins invasion and life-threatening infections. The gut microbiome is essential for maintaining intestinal epithelium integrity, modulating metabolic and immunological processes, and protecting against colonization by invasive pathogens. Understanding the complex interplay between the gut microbiome, antibiotics, and environmental factors is essential for developing targeted
interventions to prevent and manage microbiome-associated diseases. This review aims to understand the effects of multiple antibiotics on human microbiota, including gut, oral, respiratory, skin, and vaginal microbiota.