Background: Patients undergoing spinal surgery are at risk of surgical site complications. Type 1 hydrolyzed collagen powder has been shown to aid in wound healing. Purpose: The objective of this case series was to evaluate the effect of using type 1 hydrolyzed collagen on the incidence of surgical site complications (infection and dehiscence) following spinal surgeries. Methods: Electronic medical records were queried for patients who had previously undergone spinal surgery to correct spinal deformity or to treat spinal fracture, received type 1 hydrolyzed collagen for wound application during surgery, and who had returned for at least one follow up visit between two and six weeks after surgery. All consecutive patients meeting these criteria were included for analysis. Pre-operative, operative, and post-operative data were collected on electronic case report forms. Surgical site infection was documented as per the Centers for Disease Control and Prevention definitions. Results: Fifty-four (54) patients who met the inclusion criteria were included in the study. None of the patients that received type 1 hydrolyzed collagen powder at the time of wound closure experienced wound dehiscence or surgical site infection. Conclusion: These results provide evidence that surgical site wound healing is safely supported by application of type 1 hydrolyzed collagen powder.