Histological Basis in the Study of Cyprinus Carpio Sp. Operculum Bone Scaffold as a Novel Scaffold Material for Cranio-Maxillofacial Defects - Abstract
Introduction: Carp operculum (Cyprinus carpio sp.) is being proposed as a candidate for xenograft. In this animal study using rats with bony defects, the
histological response of osteoconduction with carp operculum grafts are compared with standard bovine graft.
Methodology: Carp operculum bone and bovine ribs were implanted on calvarial bone of white male rats (Rattus novergicus). After 15 days, the calvarian
bone was harvested and histologic preparations were made. Foreign-body giant cells, osteoblasts and polymorphonuclear cells were observed for under a
light microscope.
Results: Foreign-body giant cells, osteoblasts and polymorphonuclear cells were qualitatively noted to be of similar response in both carp operculum and
bovine graft groups.
Conclusion: Histological study of carp operculum bone xenograft implant showed osteoconductive ability and similar healing process as the standard
bovine xenograft implant. Further quantitative studies and evaluation of other aspects of the carp operculum as a viable xenograft material need to be carried
out.