Introduction and Importance: This study aims to present the long-term outcomes of autologous and homologous micrografts in bone regeneration procedures for dental implant placement following sinus lift augmentation. The approach combines autologous Rigenera® micrografts with poly (lactic-co glycolic acid) (PLGA). Case Presentation: An observational study was conducted involving five patients (two males and three females), aged between 36 and 71. All subjects were in good systemic health (ASA I or II), with no systemic diseases or medication intake that could interfere with osseointegration. Clinical Discussion: Radiographic evaluations following implant placement and during a continuous follow-up period of up to seven years were performed using periapical endoral radiographs. Both implant survival and success rates reached 100%. Histological assessments were carried out three and seven months post-surgery. Conclusion: No adverse events were reported related to the use of autologous micrografts combined with PLGA. The findings suggest a safe and predictable treatment approach, with positive long-term outcomes.