Prognostic Value of Plasma Diquat Concentration in Acute Oral Diquat Poisoning Patients: A Retrospective Study - Abstract
Background: Diquat (DQ) poisoning is an important public health and social security agency. This study aimed to develop a prognostic model and evaluate the prognostic value of plasma DQ concentration in patients with acute oral DQ poisoning, focusing on how its impact changes over time after poisoning. Methods: This was a retrospective study using time-dependent Cox regression analyses on 80 patients with acute oral DQ poisoning at our hospital between January 2019 and May 2022.Results: Overall in-hospital case fatality rate was 36.25% (29/80). The Schoenfeld residual of plasma DQ concentration on admission is evidence of the violation of the proportional hazards assumption. Plasma DQ concentration on admission (HR = Exp (0.032-0.059×ln(t))) and PSS within 24 h of admission (HR: 4.470, 95%CI: 1.604 ~ 12.452, P = 0.004) were independent prognostic factors in time-dependent Cox regression model. The HR of plasma DQ concentration on admission gradually decreased with time. AUROC of plasma DQ concentration on admission was higher than ingestion amount at each time point. Conclusions: Plasma DQ concentration on admission and PSS within 24 h of admission are independent prognostic factors for in-hospital case fatality rate of patients with acute oral DQ poisoning. The prognostic value of plasma DQ concentration decreased with time.