Objective: To identify the predictors of female extramarital sexual intercourse EMSI. Methods: This analytical cross-sectional study was carried out between January 15th and April 30th, 2018. Women who reported engaging in EMSI or not were recruited. Sociodemographic variables were recorded. Fisher exact test, t-test and logistic regression were used for comparison. P<0.05 was considered statistically significant. Results: Fifty six women engaged in EMSI and 154 not. Significant factors associated with EMSI were daily thinking about having SI (aOR 47.18, 95%CI 2.67-833.08), sexual dissatisfaction (aOR 44.14, 95%CI 3.77-517.15), physical distance between the couple (aOR 21.58, 95%CI 2.50-186.57), previous sexual partners ?4 (aOR 20.90, 95%CI 2.04 214.43), female level of education above husband’s own (aOR 10.42, 95%CI 1.27-85.79) and lack of dialogue within the couple (aOR 5.71, 95%CI 1.26-25.97). Twenty two (39.3%) women practicing EMSI contracted sexually transmitted infections (STI) including AIDS. Conclusion: EMSI exposed women to STI including AIDS.