Psychological stress stands as a prevalent form of stress that significantly influences both the physical and mental well-being of healthy individuals. As research delves deeper into this realm, the pathogenic mechanisms underlying psychological stress have gradually come to light, particularly its detrimental effects on sperm motility. Notably, oxidative stress has emerged as a pivotal factor in male infertility, and the excessive generation of reactive oxygen species (ROS) is a well-documented consequence of psychological stress, occurring either directly or indirectly. Drawing upon the intricate interplay between these three phenomena, this review offers a comprehensive overview, reinforcing the hypothesis that psychological stress in males can adversely affect sperm motility by eliciting oxidative stress in vivo through the overproduction of ROS. By elucidating this connection, we aim to provide insights into the potential mechanisms that underlie the negative impact of psychological stress on male reproductive health.