The process of wound healing requires multiple biological stages, which depend on both local tissue elements and the psychological and neuroendocrine systems of the body. The body experiences chronic stress, which leads to wound healing problems because it disrupts cortisol production and causes both inflammatory responses and immune cell movement and blood vessel development. Humans use sexual activity as a natural behavior that helps them to decrease stress levels while boosting their mood and sleep quality, together with their hormonal and immune system functions. The review presents evidence that shows that consensual sexual activity helps to accelerate wound healing through its effects on psychological stress reduction and its optimization of psychoneuroimmunological processes. The research team demonstrates that sexual activity decreases cortisol levels while increasing oxytocin and endorphins, together with improved vagal tone and better immune system function, which leads to their conclusion. Research studies have not examined the connection between sexual activity and wound healing yet, but evidence from adjacent fields demonstrates how sexual activities can help with tissue repair. The researchers examine animal research studies together with human observational studies and stress-wound experimental models to better understand this relationship between sexual activity and wound healing. The researchers discuss the study’s limitations through their examination of methodological aspects, ethical requirements, and confounding elements. The researchers present a new conceptual framework together with future research directions, which will allow scientists to study sexual activity as an extra non-drug therapy for wound management. The relationship between intimacy and stress regulation, together with healing processes, will create new approaches to recovery, which will improve patient well-being.