Objective: To prevent and reduce the risk of spinal infections by analyzing the underlying causes of non-operative spinal infections. Methods: By analyzing the case data of 69 patients with non-operative spinal infection in our hospital from 2019 to 2024, the potential etiology of nonoperative spinal infection was sought and analyzed. Results: 1) 69 patients with non-operative spinal infection, 35 males and 34 females, with an average age of 63.55 years; among them, 45 cases (65.22%) were over 60 years old. 6 cases (8.69%) were younger than 36 years old. There were 18 cases (26.09%) in middle-aged people aged between 36 and 59. 2) Among the 69 patients, 25 (36.23%) were urban residents; There were 44 people living in rural areas, accounting for 63.77%. 3) Among the 69 patients with non-operative spinal infection, 48 (69.57%) were complicated with sleep disorders, of which 14 slept less than 4 hours per night and 34 slept 4-6 hours per night; 21 people (30.43%) slept 6 hours a night. 4) Among 69 patients with non-operative spinal infection, 47 had abnormal defecation, accounting for 68.12%, 40 had constipation, 7 had diarrhea, and 22 had normal defecation, accounting for 31.88%. 5) Among the 69 patients, there were 16 patients with hypertension, 16 patients with diabetes, 13 patients with pulmonary diseases, 12 patients with more than one year’s history of surgery at non-infected sites, 10 patients with heart disease, 10 patients with tumor, 7 patients with autoimmune diseases (including rheumatoid arthritis, ankylosing spondylitis, and Bercet’s disease), 8 patients with drinking history, and 6 patients with smoking history. Other diseases (including cerebrovascular diseases, liver diseases, kidney diseases, osteoporosis, etc.) 15 patients. 6) The number of affected vertebrae in 69 patients with non-operative spinal infection was 93 in the lumbar spine, 49 in the thoracic spine and 10 in the cervical spine, accounting for 61.18%, 32.24% and 6.58%, respectively. The affected vertebrae of lumbar spine were L3 (15.13%), L4 (14.47%), L2 (12.50%), L5 (11.18%), L1 (7.89%). The affected vertebrae of the thoracic vertebrae were mainly concentrated in T8-T12, with T9 (5.92%), T11 (5.26%), T12 (5.26%), T10 (4.60%), and T8 (3.29%) in descending order. There were fewer affected vertebrae in the cervical spine, mainly concentrated in C4-C6, C5 (1.97%), C6 (1.32%), C4 (1.32%) from most to least affected. Conclusion: This article briefly describes the relationship between aging (advanced age), sleep disorders (insomnia), defecation disorders (intestinal flora disorders) and non-operative spinal infection. Advanced age, insomnia, and abnormal bowel movements may be potential causes of non-operative spinal infections.