Size In Breast Invasive Ductal Carcinoma Leads Changes in Important Biological Parameter - Abstract
Introduction: We analyzed the behavior of certain clinical and biological aspects in breast invasive ductal carcinomas (IDC) when tumor size increased up to three centimeters.
Material and Methods: We studied 627 women affected by IDC and aged between 29 and 88 years (median 62), classified into three groups: = 0.5 cm: 45; between 0.51 and 1 cm: 180 and 1.1 to 3 cm: 402 cases. The analyzed clinical and biological parameters were: axillary lymph node involvement (N), distant metastasis (M), immunohistochemical expression of estrogen receptors (ER), progesterone receptors (PgR), androgen receptors (AR), p53, Ki67, bcl2, and cytosolic concentrations of cathepsin D and hyaluronic acid (HA), as weel as the epidermal growth factor receptor (EGFR), HA, CD44v5 and CD44v6 in cell membranes
Results: Tumors <1 cm showed no statistical differences among all analyzed parameters. Tumors with size range between 1.1 and 3 cm presented, compared with size less than or between 0.5 and 1 cm, higher concentrations of cathepsin D (p = 0.001) increased expression of p53 (p <0.0001), ki 67 (p <0.0001), CD44v5 (p: 0.008), axillary lymph node involvement (p <0.0001), distant metastasis (p = 0.026), and decreased expression of bcl2 (p: 0.057) and membrane HA (p: 0.051).
Conclusions: Our results suggest that it is from one cm in size when is evidenced in invasive ductal breast carcinomas certain clinical and biological properties source of increased proliferation and tumor aggressiveness.