T3 Directly Regulates Epithelial Morphogenesis via E-CadherinCatenins-Rac1 - Abstract
Recent findings of our group show strong evidences that T3 is a direct regulator of gastrointestinal epithelial morphogenesis via E-cadherin-catenins-Rac1 pathway. Thus, T3 differentially mediate cell proliferation and differentiation promoting the configuration and functionality of the epithelial barrier. By using gene expression, bioinformatics and morphometric tools we have demonstrated this physiological signaling route. Our results open therapeutic possibilities not only for thyroid disorders management, but also for pathological imbalances between cell proliferationdifferentiation events that occur in diseases such as colon cancer.