Comparison Between Hydrozincite and Zinc Oxide on The Healing of Deep Wounds Using a Rat Model - Abstract
According to the prescription of zinc oxide ointment for wound healing, the pharmacological actions of zinc oxide in the ointment are written to be wound astringent, anti-inflammatory, and antiseptic. There are various types of basic zinc compounds such as zinc oxide, and hydrozincite has been known as one of them. In this study, hydrozincite was proposed as a new wound-healing ceramic alternative to zinc oxide, and the effects of zinc oxide and hydrozincite on deep wound healing were compared using a rat model. The residual wound area of hydrozincite was significantly lower than that of zinc oxide and commercial wound dressing at 2 and 4 weeks of healing time. In histological evaluation, zinc oxide-applied wounds showed poor granulation and inflammatory cell infiltration for 1-2weeks, and zinc oxide powder remained in the poor granulation tissue. On the other hand, benign granulation tissue at which hydrozincite was applied to wounds was observed at 1 week with inflammatory cell infiltration. The inflammation ended after 2 weeks, and fibroblasts were observed in the regenerated skin tissue. From these results, hydrozincite was found to be a new candidate ceramic for wound healing alternative to zinc oxide.